{"id":9662,"date":"2025-09-27T15:01:34","date_gmt":"2025-09-27T13:01:34","guid":{"rendered":"https:\/\/dermacademy.it\/immunonova-levoluzione-dei-trattamenti-per-la-vitiligine\/"},"modified":"2026-05-26T15:10:04","modified_gmt":"2026-05-26T13:10:04","slug":"immunonova-the-evolution-of-vitiligo-treatments","status":"publish","type":"post","link":"https:\/\/dermacademy.it\/en\/immunonova-the-evolution-of-vitiligo-treatments\/","title":{"rendered":"ImmunoNova: The Evolution of Vitiligo Treatments"},"content":{"rendered":"

What Vitiligo Really Is<\/h2>\n

Vitiligo is an autoimmune disease: the immune system \u201ctargets the wrong cells\u201d and attacks the melanocytes<\/strong>, causing lighter patches on various areas of the body (face, hands, elbows, knees, genitals). It is neither painful nor contagious, but it can have a significant psychological impact. The skin is where the disease manifests itself, not necessarily where it originates.<\/p>\n

From a Local Approach to a Systemic Vision: Why a Change Was Needed<\/h2>\n

Exclusively \u201clocal\u201d therapies (only creams or only light therapy) risk extinguishing the fire on the surface without reducing the immune activation that fuels new patches. In our experience and in the scientific literature, topical treatment alone is not enough to prevent progression and recurrence: a pathway capable of rebalancing immunity and promoting safe repigmentation is required.<\/p>\n

From the Counterphasic Protocol to ImmunoNova: What Changes<\/h2>\n

The counterphasic protocol represented an important step in our internal evolution. ImmunoNova represents its clinical advancement<\/strong>: a proprietary protocol integrating five pillars, with periodic monitoring and optimized adherence (a single daily treatment window, usually in the evening).<\/p>\n

The 5 Pillars of ImmunoNova<\/a><\/h2>\n
    \n
  1. Clinical Evaluation and VAI<\/strong><\/li>\n<\/ol>\n

    Specialist consultation, Wood\u2019s lamp photography, and calculation of the Vitiligo Activity Index to define disease activity, extent, and therapeutic goals.<\/p>\n

      \n
    1. Gut Health and Barrier Function<\/strong><\/li>\n<\/ol>\n

      Medical history assessment and targeted nutrition to address gastrointestinal dysfunctions (leaky gut), which may contribute to a pro-inflammatory state.<\/p>\n

        \n
      1. Microbiota and Vitamin D3<\/strong><\/li>\n<\/ol>\n

        Immunoregulatory probiotic strains and Vitamin D3 supplementation with periodic monitoring: modulation of immune response and support for melanogenesis.<\/p>\n

          \n
        1. Home-Based NB-UVB Phototherapy<\/strong><\/li>\n<\/ol>\n

          Daily use, in sub-erythemal doses, with certified devices: in our experience, this is the most effective and sustainable long-term option, even for extensive areas.<\/p>\n

            \n
          1. Topical Therapies<\/strong><\/li>\n<\/ol>\n

            Immunomodulators during active phases and melanocyte-stimulating agents during quiescent phases, selected according to body area, extent, and tolerability.<\/p>\n

            The entire pathway is organized into an \u201cevening block\u201d (between dinner and post-dinner hours) to improve adherence and therefore real-life effectiveness.<\/p>\n

            Evidence and Realistic Expectations<\/h2>\n
              \n
            • The face and \u201cfast-response\u201d areas<\/strong> often improve more quickly; hands and distal phalanges<\/strong> require more time and consistency. Every area has clinical importance and should be followed through monitoring and periodic adjustments.<\/li>\n
            • Adherence<\/strong> is crucial: when adherence is high, the percentage of consultations showing improvement increases significantly in our internal data.<\/li>\n
            • Timing and outcomes vary according to age<\/strong>, disease duration<\/strong> and activity<\/strong>, affected areas<\/strong>, comorbidities, and individual response.<\/li>\n<\/ul>\n

              The Difference in Summary: Counterphasic vs ImmunoNova<\/h2>\n
                \n
              • Approach:<\/strong> from the sequential focus of the counterphasic method to an integrated 5-pillar model<\/strong>.<\/li>\n
              • Clinical target:<\/strong> not only repigmentation, but also reducing immune activation<\/strong> and preventing new patches<\/strong>.<\/li>\n
              • Adherence:<\/strong> treatment concentrated into a single moment<\/strong> of the day, with follow-ups every 2\u20134 months.<\/li>\n
              • Personalization:<\/strong> therapeutic choices modulated according to VAI, affected areas, comorbidities, and patient preferences.<\/li>\n<\/ul>\n

                Would you like to understand whether the ImmunoNova<\/strong> protocol for vitiligo may be suitable for you?<\/p>\n

                Book a consultation or request an evaluation with our team.<\/p>\n","protected":false},"excerpt":{"rendered":"

                What Vitiligo Really Is Vitiligo is an autoimmune disease: the immune system \u201ctargets the wrong cells\u201d and attacks…<\/p>\n","protected":false},"author":11,"featured_media":9663,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[57],"tags":[61],"class_list":["post-9662","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog","tag-dermatology"],"acf":[],"_links":{"self":[{"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/posts\/9662","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/comments?post=9662"}],"version-history":[{"count":2,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/posts\/9662\/revisions"}],"predecessor-version":[{"id":10622,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/posts\/9662\/revisions\/10622"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/media\/9663"}],"wp:attachment":[{"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/media?parent=9662"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/categories?post=9662"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/dermacademy.it\/en\/wp-json\/wp\/v2\/tags?post=9662"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}